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(Nitric Oxide)

What is it?

NO2 is the amino acid arginine and arginine alpha-ketoglutarate (AKG) repackaged with a new name.

Does it occur naturally in the body?

Nitric oxide is produced naturally by the body to protect the heart, stimulate the brain and kill bacteria.

What are the claims?

NO2 is supposed to create and sustain levels of nitric oxide in the skeletal muscles. Supposedly elevated levels of nitric oxide enhance oxygen delivery, glucose uptake, muscle velocity and muscle growth.

Does it work?

That all depends on the type of results you're looking for. A study conducted at Baylor University (Texas) examined the effects of AKG supplementation during training on body composition and training adaptations in experienced gym users. At the end of the trial, no significant differences were observed in the AKG users in body mass, fat-free mass, fat mass or percentage of body fat. There were changes in bench press one-repetition maximum. The conclusion of the study was that AKG supplementation might augment one-repetition maximum strength in response to training but does not appear to affect body composition.

In a study at University Medical Centre Hamburg-Eppendorg, researchers wanted to see if giving arginine supplementation to subjects would raise their arginine levels. Calling Captain Obvious! Yup, taking arginine supplements DID raise arginine levels in test subjects. What they failed to test was if those raised levels increased strength, muscle mass or endurance. As of 9/28/2008, we are still waiting for studies to show who should take NO Boosters, how much is clinically beneficial, what form that supplement should be taken in and, what results can be expected.

All the NO Booster ads talk about how the body increases muscle, but none of them have studies showing THEIR product can stimulate muscle.

What are the dangers?

Documented dangers that occur from overdosing on arginine (the primary ingredient of NO2) include diarrhea, weakness and nausea.

The Bottom Line

NO2 does not contribute to changes in body mass, fat-free mass, fat mass or percent of body fat. The primary ingredient is arginine, which has been shown to have no beneficial muscle-building effects.

We cannot recommend the supplement NO2 until conclusive studies on dosage, effectiveness and proper delivery methods are conducted.

Links for More Info

Centers for Disease Control and Prevention (CDC) Logo and Link
Centers for Disease Control and Prevention

United States Food and Drug Administration (FDA)

Herbs, Botanicals & Other Products - Extensive Information from the Memorial Sloan-Kettering Cancer Center

National Center for Complementary and Integrative Health - Overviews on Herbal Treatments and Supplements

National Institutes of Health

National Institutes of Health - Office of Dietary Supplements
National Institutes of Health - Office of Dietary Supplements

Operation Supplement Safety
Operation Supplement Safety

United States Department of Agriculture (USDA) Logo and Link
United States Department of Agriculture

WebMD Logo and Link
WebMD - Helping you make better decisions for life.

We at WeBeFit DO NOT recommend ANY supplements to ANY of our clients. ONLY a licensed Nutritionist or Medical Doctor can make those recommendations based on your individual needs.

This is being provided for INFORMATIONAL and EDUCATIONAL purposes only.

CAUTION: These supplements have not been evaluated by the Food and Drug Administration (FDA) for safety, effectiveness or purity. There may be unknown risks associated with taking any supplements. There are no regulated manufacturing standards for companies that make supplements. There have been instances where herbal or health supplements have been sold that were contaminated with toxic substances. If you should choose to purchase herbal or health supplements, please only purchase them from a reliable source to minimize the risk of contamination.

If you should decide to use ANY supplement, ALWAYS consult your doctor or Nutritionist first.